Box 1 | Simplified topogenic map of the cell The concept of protein 'topogenesis', proposed by Gunter Blobel in 1980 (REF. 5), was an outgrowth of the original signal hypothesis. It states that the localization and disposition of proteins in the membrane compartments of the cell are determined by topogenic signals (often called sorting signals) that are encoded in polypeptide chains (see the figure). The cell in which the genes are expressed deciphers the signals and facilitates their transport to the correct location. Proteins directed to locations on the secretory pathway (organelles and plasma membrane) have endoplasmic reticulum (ER) translocation signals and topogenic signals to direct them to their ultimate destinations once they enter the ER. Many topogenic signals are short peptides, such as the ER translocation signa
Gunter blobel signal hypothesis animation examples
What is the signal hypothesis
Gunter blobel signal hypothesis animation model
Gunter blobel signal hypothesis animation system
| Gunter blobel signal hypothesis animation examples |
What is the signal hypothesis |
| Gunter blobel signal hypothesis animation model |
Gunter blobel signal hypothesis animation |